Management of Calcium Channel Antagonist Overdose with Hyperinsulinemia-Euglycemia Therapy: Case Series and Review of the Literature

Table 1

Case reports of calcium channel antagonist overdose using hyperinsulinemia therapy with clinical outcomes.

CCA ingested	Dose range (mg)	Number of patients (%)	Insulin bolus (IU/kg)	Insulin infusion (IU/kg/hr)	Duration of treatment	Survival N (%)
Verapamil	2000–5800	10 (40)	0–1000 units; (no IU/kg reported)	0-1	8–33 hours	9 (90)
Diltiazem	900–10080	9 (24)	0-1	0.2–1.5	6–8 hours	6 (67)
Amlodipine	30−1000	9 (36)	0-1	0–2.64	6–49 hours	8 (88)