Multiple Congenital Granular Cell Epulis: Case Report and Immunohistochemical Profile with Emphasis on Vascularization

Figure 2

Histological and immunohistochemical sections. (a) Large round granular cells with an abundant eosinophilic cytoplasm and basophilic nuclei in a background of prominent vasculature and lined by an atrophic epithelium (H&E 200x). (b) Granular cells demonstrating strong positivity for CD68 (400x). ((c) and (d)) Endothelial cells positive for CD105 and CD34, respectively. (e) D2-40 positive immunostaining for granular cells and lymphatic vessels. (f) Weak staining for Ki67, showing a low grade of proliferation. ((g) and (h)) Overexpression of VEGF and FGF in granular cells and endothelial cells, respectively.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)