Acantholytic Pityriasis Rubra Pilaris Associated with Imiquimod 3.75% Application
Figure 2
Skin biopsy, left abdomen. Alternating parakeratosis and orthokeratosis in the stratum corneum in vertical and horizontal sections. A focus of acantholysis in the epidermis with suprabasilar and subcorneal location. Within the superficial dermis, there is a sparse superficial perivascular and interstitial lymphocytic infiltrate. Hematoxylin-eosin stain (a) ×4 and (b) ×20 magnification.
