Familial Kaposi’s Sarcoma: A Report of Five Cases from Greece

Table 1

Characteristics of the patients with KS.

Family	Relationship	Age at the time of diagnosis	Age of onset	Type of KS	Location of the lesion	Duration; (years)	Extracutaneous involvement	Risk factors	Treatment
1	Father	78	60	Reddish-brown macules and reddish-violaceous infiltrated plaques	Right thigh, calves, feet (including the toes), and hands	18	None	Diabetes mellitus type II	Interferon A-2a sc
	Son	36	33	Reddish-purple macules and irregular plaques	Thighs, knees, left forearm, the area of the right achilles tendon, and the middle finger of the left hand	3	None	None	Gel alitretinoin 0.1%
2	Mother	72	71	Reddish-violaceous papules, nodules, and infiltrated plaques	Chest, abdomen, back, and both arms and legs	1	None	None	Interferon A-2a sc
	Son	51	51	Reddish-brown papules and nodules	Abdominal area, right chest wall, left buttock, both thighs, both the medial malleoli areas, and the toes of both feet	1	None	Diabetes mellitus type II	Gel alitretinoin 0.1%, doxorubicin pegylated 20 mg/m^2
3	Sister	72	69	Reddish-violaceous papules and nodules	Right lateral, medial malleolus area	3	None	None	Radiotherapy
	Sister	51	51	Reddish-purple nodules and infiltrating plaques	Both hands, knees, calves, and feet	3 months	None	None	Gel alitretinoin 0.1%
4	Brother	65	65	Reddish-purple macules and irregular plaques	Both thighs, knees, and the right forearm	8 months	None	None	Cryosurgery, gel alitretinoin 0.1%
	Brother	79	79	Reddish-purple macules	Lower extremities	7 months	None	Diabetes mellitus type II, hypertension	Interferon A-2a sc
5	Father	75	73	Reddish-purple macules and irregular plaques	Both legs	2	None	Diabetes mellitus type II	Gel alitretinoin 0.1%
	Son	57	57	Reddish-purple nodules and infiltrating plaques	Left hand and knees	3 months	None	None	Cryosurgery