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Family | Relationship | Age at the time of diagnosis | Age of onset | Type of KS | Location of the lesion | Duration (years) | Extracutaneous involvement | Risk factors | Treatment |
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1 | Father | 78 | 60 | Reddish-brown macules and reddish-violaceous infiltrated plaques | Right thigh, calves, feet (including the toes), and hands | 18 | None | Diabetes mellitus type II | Interferon A-2a sc |
Son | 36 | 33 | Reddish-purple macules and irregular plaques | Thighs, knees, left forearm, the area of the right achilles tendon, and the middle finger of the left hand | 3 | None | None | Gel alitretinoin 0.1% |
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2 | Mother | 72 | 71 | Reddish-violaceous papules, nodules, and infiltrated plaques | Chest, abdomen, back, and both arms and legs | 1 | None | None | Interferon A-2a sc |
Son | 51 | 51 | Reddish-brown papules and nodules | Abdominal area, right chest wall, left buttock, both thighs, both the medial malleoli areas, and the toes of both feet | 1 | None | Diabetes mellitus type II | Gel alitretinoin 0.1%, doxorubicin pegylated 20 mg/m2 |
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3 | Sister | 72 | 69 | Reddish-violaceous papules and nodules | Right lateral, medial malleolus area | 3 | None | None | Radiotherapy |
Sister | 51 | 51 | Reddish-purple nodules and infiltrating plaques | Both hands, knees, calves, and feet | 3 months | None | None | Gel alitretinoin 0.1% |
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4 | Brother | 65 | 65 | Reddish-purple macules and irregular plaques | Both thighs, knees, and the right forearm | 8 months | None | None | Cryosurgery, gel alitretinoin 0.1% |
Brother | 79 | 79 | Reddish-purple macules | Lower extremities | 7 months | None | Diabetes mellitus type II, hypertension | Interferon A-2a sc |
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5 | Father | 75 | 73 | Reddish-purple macules and irregular plaques | Both legs | 2 | None | Diabetes mellitus type II | Gel alitretinoin 0.1% |
Son | 57 | 57 | Reddish-purple nodules and infiltrating plaques | Left hand and knees | 3 months | None | None | Cryosurgery |
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