Methylprednisolone Therapy in Acute Hemorrhagic Edema of Infancy

Table 1

Clinical differences between acute hemorrhagic edema of infancy (AHEI) and Henoch-Schönleins purpura (HSP).

Clinical findings	AHEI	HSP
Peak incidence	4 to 24 months	4 to 7 years
Skin distribution	Faces, auricles, and extremities	Extensor surfaces of the legs and buttocks
Edema	Consistent,; nonpitting	Inconsistent
Gastrointestinal involvement	Rare	Common
Articular involvement	Rare	Common
Renal involvement	Extremely rare	Common
Skin histology	Leukocytoclastic vasculitis, frequently with fibrinoid necrosis	Leukocytoclastic vasculitis
Perivascular deposits	C1q	IgA
Duration	2-3 weeks	1 month or more
Relapses	Rare	Frequent