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| Author and year | Age/sex | Size of adenoma | Dominant clinical presentation | Acromegaly evaluation | Cushings evaluation | Pattern of stains |
|
| Arita et al. 1991 [1] | 29/F | 1.6 cm | Acromegaly and Cushing's | GH 92 ng/mL
| ACTH 94 pg/mL | Diffuse GH stainings and focal ACTH staining in the tumor tissue |
| Blevins et al. 1992 [2] | 40/F | 1.3 cm | Acromegaly and Cushing's | GH 22 ng/mL
Nonsuppression of GH with OGTT
| UFC 731 nmol/d (66–298)
Nonsuppression of UFC with 2 mg Dexamethasone | Two discrete cell groups each staining diffusely for GH and ACTH, respectively |
| Apel et al. 1994 [3] | 76/F | 2.2 cm | Acromegaly | GH 13.7 ng/mL (<5)
IGF-1 464 ng/L (116–270) | ACTH 6.5 pmol/L (<22)
PRL 25.8 mcg/L (<17.9) | Two discrete areas of GH and ACTH staining |
| Kovacs et al. 1998 [4] | 62/M | >1 cm** | Acromegaly | GH 13.7 ng/mL (<5)
IGF-1: 973 ng/L (48–275)
| Not available | Majority of cells displayed variable positivity for GH, whereas the minority of adenoma cells were strongly stain for ACTH; occasional cells positive for PRL |
|
Mazarakis et al. 2001 [5] | 53/M | 1.5 cm | Acromegaly | GH 17.5 ng/mL
IGF-1 934 ng/mL | ACTH 29 pg/mL (<52)
No hypercortisolism documented | Chromophobic tumor, immunoreactive for GH focally admixed with hyperplastic PAS positive, and ACTH immunoreactive cells showing the electron microscopic features characteristic of corticotrophs |
| Kageyama et al. 2002 [6] | 45/F | 1.2 cm | Acromegaly | GH 20.9 ng/mL (<3.1)
IGF-1 650 ng/mL (46–282)
| ACTH 91 pg/mL (<60)
Urine-free cortisol 403 mcg/d (40–140)
LDST-Cortisol Nonsuppression
HDST-cortisol suppression | 2 distinct types of tumor cells, with either diffuse but faint GH-positive cells or sparse but distinct ACTH-stained cells; few PRL positive cells detected as well |
| Tsuchiya et al. 2006 [7] | 54/M | 1.2 cm | Acromegaly | GH: 31.5 ng/mL (<0.6)
IGF-1: 493 ng/mL (106–398) | ACTH: 53 pg/mL (7–56)
UFC: 45.6 mcg/d (<80.3)
LDST-Cortisol Nonsuppression
HDST-cortisol suppression
| Diffuse GH and PRL staining and focal ACTH staining in the tumor tissue |
| Oki et al. 2009 [8] | 36/M | >1 cm** | Acromegaly | GH 6.33 ng/mL
IGF-1: 1361.3 ng/mL (67–318)
| ACTH 91.7 pg/mL
LDST-Cortisol Nonsuppression
HDST-cortisol suppression | Tumor cells with diffuse strong GH stain and focal staining with ACTH and TSH |
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