Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine: Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry
Figure 1
Light microscopy image (a) and TOF-SIMS image (b) of the tissue section from the PTU pretreated patient. The green in the TOF-SIMS image represents the signal from iodine and the red marks (signal from cell membranes). Iodine signals were mainly found within the follicle lumina but also in some areas outside the follicles, presumably in the thyrocytes. The iodine concentration was inhomogeneously distributed within some follicle lumina.
