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Case Reports in Endocrinology
Volume 2012 (2012), Article ID 875764, 5 pages
http://dx.doi.org/10.1155/2012/875764
Case Report

Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers?

1Division of Hematology/Oncology, Tufts Medical Center, Tufts University School of Medicine, MA, USA
2The Hospital of Central Connecticut, New Britain, CT 06489, USA
3Oncology Unit GPP, Sotiria General Hospital, Athens School of Medicine, Mesogeion 152, 115 27 Athens, Greece

Received 21 September 2012; Accepted 3 October 2012

Academic Editors: M. Demura and R. Swaminathan

Copyright © 2012 M. W. Saif et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Adrenocortical carcinoma (ACC) is a rare and aggressive tumor arising from the adrenal cortex with an incidence of one to two cases per million within the general US population. Recent developments in the understanding of the pathogenesis of ACC have led to multiple clinical trials involving targeted agents in the management of ACC. Patients and Methods. We report two cases of refractory adrenocortical cancer (cisplatin, adriamycin, etoposide, and mitotane) who were treated with targeted agents such as erlotinib and sutent, respectively. A total of 2 women with adrenocortical cancer were reviewed and followed for a median time of 6 months. Radiological response, duration of response and toxicities were evaluated. Results. In both cases, the targeted agents were able to control the disease for a short duration, but due to the deterioration in performance status and fatigue the agents were discontinued. Conclusion. The current observations emphasize the need for better targeted treatment modalities and strategies for the management of this fatal disease.