Syndrome of Inappropriate Antidiuretic Hormone Secretion and Ibuprofen, a Rare Association to Be Considered: Role of Tolvaptan

Table 1

Published cases of NSAID-induced SIADH.

Authors	Reference	No. of pts.	Initial sodium levels (mmol/L)	Therapy	Drug involved
Temple et al.	[13]	2	131–134	Mannitol/fluid restriction	Salicylate
Blum and Aviram	[14]	1	115	Fluid restriction	Ibuprofen
Dunn et al.	[15]	2	118; 118	Fluid restriction; Fluid restriction	Ibuprofen; Diclofenac
Petersson et al.	[16]	2	119; 120	Hypertonic saline; Isotonic saline/fluid restriction	Piroxicam; Diclofenac
Cheung et al.	[17]	1	116	Fluid restriction	Nabumetone/diclofenac
Rault	[18]	1	125	Isotonic saline	Ibuprofen
Shimada et al.	[19]	1; (twice)	118; 104	Fluid restriction	Metamizole; Propyphenazone