Anticytotoxic T-Lymphocyte Antigen-4 Induced Autoimmune Hypophysitis: A Case Report and Literature Review
Table 2
Toxicity grading and endocrine adverse events associated with immune checkpoint inhibitors, according to Common Terminology Criteria for Adverse Events (CTCAE) of National Institutes of Health (National Cancer Institute) [2].
Endocrine adverse event
Grade
Description
Hypothyroidism
1
Asymptomatic; clinical or diagnostic observations only; intervention not indicated
2
Symptomatic; thyroid replacement indicated; limiting instrumental activity of daily living (ADL)
3
Severe symptoms; limiting self-care ADL; hospitalization indicated
Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
2
Moderate; minimal, local or noninvasive; intervention indicated; limiting age-appropriate instrumental ADL
3
Severe or medically significant but not immediately life-threatening; symptoms; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self-care ADL