Case Report

Temozolomide-Induced Shrinkage of Invasive Pituitary Adenoma in Patient with Nelson’s Syndrome: A Case Report and Review of the Literature

Table 2

The process of TMZ treatment of corticotroph pituitary adenoma in Nelson’s syndrome in our patient.

Stage of treatment with TMZClinical symptomsACTH (pg/mL)
normal range
7.2–63.3
MRI, volume (mL) of the tumor

Before treatmentRecurrent headaches and blindness of the right eye due to optic chiasm compression 23830 16.137

After the first cycle Return of light sensitivity in right eye 12110

After three cycles Further conspicuous improvement of vision in right eye. Improvement of general appearance and feeling and reduction of hypotension drugs and daily insulin doses9215 12.935
Reduction in tumor volume of 19.8% (3.202 mL)

After six cycles Further improvement of vision in right eye and general condition of the patient5712 11.725
Further reduction in tumor volume of 9.3%
(1.21 mL)

According to local laboratory 2012.