Life-Threatening Hypercalcemia due to Graves’ Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature

Table 2

Signs, symptoms, and treatment regimens of the reported cases.

Case	Signs/symptoms	Treatment	R
1	Anorexia, weight loss, fasting hypoglycemia, and mental aberrations	IVH, Di	[12]
2	Weakness, anorexia, orthostatic dizziness, failure to lactate, and weight loss	BB, C	[13]
3	Myalgia, anorexia, nausea, vomiting, weight loss, and failure to lactate	IVH, C	[14]
4	Lethargy, anorexia, vomiting, and weight loss	IVH, C, AT, RAI	[15]
5	Fatigue, weakness, nausea, vomiting, myalgia, arthralgia, and weight loss	C	[16]
6	Lethargy, myalgia, arthralgia, myopathy, nausea, vomiting, anorexia, weight loss, and failure to lactate	C, AT	[17]
7	Confusion, tachycardia, and dehydration	C, RAI	[17]
8	Disturbed mental state, severe nausea, vomiting, increased thirst, polyuria, and weight loss	AT, C, DDAVP	[4]
9	Anorexia, diarrhea, night sweats, myalgia, and weight loss	IVH, BP, AT, C	[18]
10	Headache, anorexia, weakness, fever, tachycardia, mental changes, and failure to lactate	C, IVH, KI, AT, BB	[19]
11	Nausea, vomiting, fever, and lethargy	C	[7]
12	Anorexia, nausea, vomiting, and severe dehydration	C, IVH	[20]
13	Vomiting and diarrhea	IVH, BB, C	[21]
PC	Vomiting, nausea, constipation, and weight loss	IVH, C, Di, BP, AT, BB

R, reference; IVH, intravenous hydration; Di, diuretic; BB; beta blocker; C, corticosteroid; AT, antithyroid drugs; RAI, radioactive iodine treatment; DDAVP, 1-deamino-8-D-arginine vasopressin; BP, bisphosphonate; KI, potassium iodide; PC, present case.