Pegvisomant-Induced Cholestatic Hepatitis in an Acromegalic Patient with UGT1A1<svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.06579971pt" id="M1" height="13.3047pt" version="1.1" viewBox="-0.0657574 -13.2389 6.34791 13.3047" width="6.34791pt"><g transform="matrix(.012,0,0,-0.012,-1.078,-7.578)"><path id="g14-43" d="M499 152C501 180 492 209 480 228C432 233 403 235 357 256C403 278 432 279 480 284C492 303 504 328 499 359C477 375 447 382 424 380C396 342 380 317 338 288C342 339 356 364 376 408C366 429 350 451 320 463C295 451 274 429 265 408C284 364 297 339 301 288C259 317 244 341 216 380C193 382 166 379 141 359C139 332 148 303 160 284C208 279 237 277 283 256C237 234 208 233 160 228C148 209 136 184 141 152C163 137 193 130 216 132C244 170 260 195 302 224C298 173 284 148 265 104C274 83 290 61 320 49C345 61 366 83 376 104C356 148 343 173 339 224C381 195 396 171 424 132C447 130 474 133 499 152Z"/></g></svg>28 Mutation

<div>Focal acinar collapse. Sinusoidal inflammatory foci with some eosinophils. Hepatocyte cytoplasmic cholestasis, HE, 400x. See arrows.</div>

Case Reports in Endocrinology

fig4

Figure 4

Figure 4: Pegvisomant-Induced Cholestatic Hepatitis in an Acromegalic Patient with UGT1A1<svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.06579971pt" id="M1" height="13.3047pt" version="1.1" viewBox="-0.0657574 -13.2389 6.34791 13.3047" width="6.34791pt"><g transform="matrix(.012,0,0,-0.012,-1.078,-7.578)"><path id="g14-43" d="M499 152C501 180 492 209 480 228C432 233 403 235 357 256C403 278 432 279 480 284C492 303 504 328 499 359C477 375 447 382 424 380C396 342 380 317 338 288C342 339 356 364 376 408C366 429 350 451 320 463C295 451 274 429 265 408C284 364 297 339 301 288C259 317 244 341 216 380C193 382 166 379 141 359C139 332 148 303 160 284C208 279 237 277 283 256C237 234 208 233 160 228C148 209 136 184 141 152C163 137 193 130 216 132C244 170 260 195 302 224C298 173 284 148 265 104C274 83 290 61 320 49C345 61 366 83 376 104C356 148 343 173 339 224C381 195 396 171 424 132C447 130 474 133 499 152Z"/></g></svg>28 Mutation 

Case Reports in Endocrinology

Pegvisomant-Induced Cholestatic Hepatitis in an Acromegalic Patient with UGT1A128 Mutation

Figure 4