The Biochemical Profile of Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism during Pregnancy and Lactation: Two Case Reports and Review of the Literature
Table 1
Summary of serum and urine biochemistry in patients 1 and 2 prior to pregnancy, during pregnancy, and during lactation.
Patient 1 (FHH)
Patient 2 (PHPT)
Reference range
Prior to pregnancy
Albumin adjusted calcium (mmol/L)
2.61 mmol/L
n/a
2.10–2.55 mmol/L
PTH (ng/L)
33 ng/L
n/a
13–54 ng/L
CCCR (%)
0.79%
n/a
<2% = possible hypocalciuria <1% = hypocalciuria
Pregnancy
Albumin adjusted calcium (mmol/L)
2.59 mmol/L
2.97 mmol/L
2.10–2.55 mmol/L
PTH (ng/L)
46 ng/L
52 ng/L
13–54 ng/L
CCCR (%)
1.99%
2.67%
n/d
Lactation
Albumin adjusted calcium (mmol/L)
2.53 mmol/L
2.96 mmol/L
2.10–2.55 mmol/L
CCCR (%)
n/a
0.89%
n/d
n/a = not available. n/d = not defined. Reference ranges are for nonpregnant and nonlactating patients.