Syndrome of Reduced Sensitivity to Thyroid Hormones: Two Case Reports and a Literature Review

Table 3

Markers of metabolism on increasing doses of levothyroxine, in both patients.

	SHBG (nmol/L)	ALP (U/I)	Ferritin (ng/mL)	Cholesterol (mg/dL)	Triglycerides (mg/dL)	SGOT (U/I)	SGPT (U/I)	Medication (levothyroxine) (μg/d)
1st patient	—	74	—	310	198	21	20	100
	18.7	81	—	—	—	20	18	200
	19.4	68	59.7	250	173	14	15	250
	21.7	80	46.5	247	165	12	15	300
	18	65	40	200	149	13	14	325
2nd patient	—	110	—	—	—	12	17	150
	8.17	125	21.1	190	55	14	16	200
	22.7	111	35.16	188	63	14	21	300

Normal values:
SHBG (sex hormone binding globulin): 18–114 nmol/L females, 13–71 nmol/L males.
ALP (alkaline phosphatase): 42–98 U/I.
Ferritin: 17–293 ng/mL males, 7–283 ng/mL females.
SGOT: 10–40 U/I.
SGPT: 10–35 U/I.