Extra Copies of der(21)t(12;21) plus Deletion of ETV6 Gene due to dic(12;18) in B-Cell Precursor ALL with Poor Outcome

Figure 1

Conventional and molecular cytogenetics dates. (a) G-banding. The arrows show add (12p), −18, and +21, +21; (b) FISH shows two copies of der(21)t(12;21) (arrows), two 21 chromosomes, and ETV6 deletion; (c) M-FISH showing the 10 trisomy and der(12)t(12;21); dic(12;18)(p12;q11.21), der(21)t(12;21), +21; (d) CEP probe 12 and 18 shows dic(12;18); (e) MCB: showing the breakpoints of the der(12)t(12;21) and der(12)t(12;18).