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Case Reports in Genetics
Volume 2012 (2012), Article ID 490408, 4 pages
Case Report

Prenatal Diagnosis of Cystic Hygroma related to a Deletion of 16q24.1 with Haploinsufficiency of FOXF1 and FOXC2 Genes

1Department of Obstetrics and Gynecology, Santa Clara Valley Medical Center, San Jose, CA 95128, USA
2Department of Pediatrics and Genetics, Santa Clara Valley Medical Center, San Jose, CA 95128, USA

Received 10 July 2012; Accepted 31 July 2012

Academic Editors: P. D. Cotter and C. López Ginés

Copyright © 2012 Matthew J. Garabedian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report the prenatal diagnosis of cystic hygroma that was subsequently identified to have haploinsufficiency of the FOXF1 and FOXC2 genes via array comparative genomic hybridization (aCGH). Deletion o f these genes has previously neither been associated with cystic hygroma nor prenatally diagnosed. The FOX gene cluster is involved in cardiopulmonary development. This case expands the phenotypic spectrum o f abnormalities of the FOXF1 and FOXC2 genes, as it seems within the spectrum of function that disruption of the FOX gene cluster would lead to include abnormalities of prenatal onset. Identification of this association would not be possible with conventional karyotype or targeted aCGH. This case highlights the power of whole genomic aCGH to further delineate the etiology of birth defects.