Detection of Chromosome X;18 Breakpoints and Translocation of the Xq22.3;18q23 Regions Resulting in Variable Fertility Phenotypes

Table 1

Theoretical meiotic segregation patterns for translocation: 46, X, t(X;18)(q22.3;q23).

Segregation type	Cell 1	Cell 2
Alternate (result is balanced or normal)^a	X + 18	der(X) + der(18)
Adjacent 1^b	X + der(18)	der(X) + 18
Adjacent 2^b	X + der(X)	18 + der(18)
Tertiary trisomy^b	X + 18 + der(X)	der(18)
Tertiary trisomy^b	X + 18 + der(18)	der(X)
Interchange trisomy^b	der(X) + der(18) + X	18
Interchange trisomy^b	der(X) + der(18) + 18	X
4 : 0^b	X + der(X) + 18 + der(18)	—

^aNormal or balanced meiotic segregation pattern.
^bAbnormal theoretical meiotic segregation pattern.