Abstract
Beckwith-Wiedemann syndrome (BWS) is a rare congenital syndrome characterized by an overgrowth, macroglossia, exomphalos, and predisposition to embryonal tumors. Central nervous abnormalities associated with BWS are rare. We describe a one-day-old Congolese female who presented meningocele associated with BWS phenotype.
1. Introduction
Beckwith-Wiedemann syndrome (BWS) is a rare congenital disorder with an incidence of one in 13.700 live births [1, 2]. Initially, its designation was EMG (exomphalos-macroglossia-gigantism syndrome) and was characterized by a triad of an overgrowth, macroglossia, and exomphalos or umbilical hernia [3]. Other features were observed being associated with the triad, such as umbilical hernia, organomegaly (liver, spleen, or kidneys), neonatal hypoglycemia, minor ear anomalies, nevus flammeus, cleft palate, or embryonal tumor development [4, 5]. The clinical features of BWS are variable, and it is accepted that the diagnosis can be established if three major diagnostic findings are present [6]. Its etiology is heterogeneous, arising from dysregulation of one or both imprinting control regions (IC) and/or imprinted growth regulatory genes of the chromosome 11p15.5 [7]. BWS occurs with the same frequency in male and female [8]. Central nervous system anomalies are rare in BWS, but as far as we know not a single case has been described presenting meningocele. Here we present a female newborn who presented meningocele associated with the BWS phenotype.
2. Case Report
The index case is a one-day-old female, born at 39 weeks of gestation via normal spontaneous vaginal delivery with a birth weight of 4400 g (+4 SD, CDC growth charts). Her mother was 27 years, her father was 30 years old, and both were healthy and unrelated. Family history was marked by a primary infertility for 10 years. The mother had many gynecological consultations and medical treatment that she ignored during the last two years. During gestation she had a urinary infection treated with amoxicillin during the first trimester and treatment of threatened miscarriage. She took clay during the entire pregnancy. She received vaccination during the second trimester of gestation. Two prenatal ultrasound scans were performed, one during the first trimester and the second during the second trimester. Both did not show any anomaly. At birth on clinical examination, we observed macroglossia with protruding tongue, nevus flammeus on her face (Figure 1(a)). She presented crumped helix on her right ear and ear creases on the left lobe (Figures 1(b) and 1(c)). She had an omphalocele containing intestines (Figure 2(a)), a lumbosacral meningocele, and bilateral club feet (Figures 2(b) and 2(c)). She developed acute respiratory distress and died within six hours after birth.
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3. Discussion
We present a newborn female, who presented an unusual association, meningocele associated with BWS phenotype. The diagnosis of BWS was based on the classical clinic triad of overgrowth, macroglossia, and exomphalos, associated with some additional minor features such as ear anomalies and frontal hemangioma. The diagnosis could not be confirmed by genetic studies, since the child died prematurely, before DNA could be obtained. The distinctive feature in the present case is lumbosacral meningocele. Central nervous abnormalities associated with BWS are rare, mostly involving the brain (reviewed in Table 1). It is not excluded that this represents a chance association of two pathogenetically unrelated conditions, and the lack of genetic testing is a weakness of this report. Alternatively, given the previous reports of CNS anomalies in other cases with BWS, it is not excluded that the underlying genetic cause of BWS may also predispose to brain malformations (including neural tube defects), especially when imprinting defect involves the imprinting domain 2 at chromosome 11p15.5 [16].
Conflict of Interests
None of the authors has a conflict of interests to disclose in relation to this work.
Authors’ Contribution
Sébastien Mbuyi-Musanzayi did clinical examination, treatment of the patient, and redaction of paper. Toni Lubala Kasole did clinical examination. Aimé Lumaka did paper correction. Tony Kayembe Kitenge did clinical examination. Leon Kabamba Ngombe did clinical examination. Prosper Lukusa Tshilobo and Prosper Kalenga Muenze did paper correction. François Tshilombo Katombe did clinical examination. Koenraad Devriendt did clinical examination, diagnosis, and paper corrections. All coauthors have read, contributed to, and approved the paper.
Acknowledgments
The authors thank the family of the patient for their kind cooperation and the Center for Human Genetics, KU Leuven, for support. Sébastien Mbuyi-Musanzayi was supported by a scholarship from interfaculty Council for Development Cooperation (IRO), KU Leuven, and GROS, Holsbeek (Belgium).