Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation

Figure 2

Muscle biopsy of the quadriceps revealed chronic active neurogenic atrophy ((a), H&E). Fiber type grouping is seen in immunoperoxidase staining for both slow myosin (b) and fast myosin (c). Some muscle fascicles are much more severely affected and show features of end stage muscle (d). Scale bar = 100 μm in panels (a) and (d); 150 μm in panels (b) and (c).

(a)

(b)

(c)

(d)