Adult Prader-Willi Syndrome: An Update on Management

Table 1

Clinical features and common medical problems in adult PWS [3].

Signs and symptoms that warrant referral to genetic service for genetic assessment of PWS in adult
History of hypotonia, poor sucking, and feeding problems during infancy
Short stature
Hypogenitalism
Hyperphagia
Obesity
Small hands and feet
Intellectual disability and/or behavioral problems
Thick, viscous saliva
Common medical problems in adult PWS
System	Medical problems
Cardiovascular	Hypertension
	Hyperlipidemia
Respiratory	Breathing related sleep disorder
	Infection like pneumonia
Endocrine	Type 2 diabetes mellitus
	Hypothyroidism
	Hypogonadism
Psychological	Psychosis
	Behavioral problems
	Sexuality
	Abuse
Dermatological	Skin picking
	Soft tissue infection like erysipelas
Musculoskeletal	Osteoporosis
Iatrogenic	Growth hormone related side effects