Case Report
Chromosomal Abnormalities in Syndromic Orofacial Clefts: Report of Three Children
Table 1
Molecular karyotype with chromosomal base pair location, size, number of genes, and critical regions in the case series.
| Proband | Molecular karyotype | Base pair location (mb) | Size (mb) | Number of genes | Critical regions |
| 1. | arr11q23.3q25 x 3; | 116.7 – 134.9 | 18.2 | 180 | Duplicated material | | arr22q11.1q11.21 x 3 | 16.1 – 20.7 | 4.6 | 65 | 2. | arr4q27q35.2 x 3; | 121.7 – 190.9 | 69 | 226 | 4q33q34 – Developmental disability and craniofacial dysmorphism 4q26q27 – Cardiac 4q25q31.3 – Urogenital | | arr21q22.2q22.3 x 1 | 40.8 – 48.1 | 7.3 | 105 | 3. | arr12p13.33p13.32 x 3; | 0.2 – 4.5 | 4.3 | 33 | 18q22.2q23 – Cleft lip palate | | arr18q22.3q23 x 1 | 70.9 – 78.0 | 7.1 | 28 |
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