Cutaneous Vasculitis, Interstitial Pneumonia with Crazy-Paving Appearance, and Positive pANCA in a Patient with Severe Crohn’s Disease
Figure 1
Skin lesions and pathologic findings. (a) A representative picture for skin nodules. ((b)–(d)) Histological examination of skin lesions showed mild atrophy of the epidermis and enormous neutrophilic and lymphocytic infiltration of adipose tissue and appendages in the dermal layer ((b), (d)); local small abscesses were formed (star) (c); in line with vasculitis, a thickening of the arterial walls of some small arteries by an inflammatory lymphoid infiltrate (snowflake) (H.E. stain ×100) (c). ((e)-(f)) Biopsy from the terminal ileum mucosa showed a granulomatous inflammatory infiltration (black bold arrow) (H.E. stain ×100) (e). Antiacid staining and PAM were negative. CD68 antigen in terminal ileum mucosa was positive (×100) (f).
