Response of Paroxysmal Nocturnal Hemoglobinuria Clone with Aplastic Anemia to Rituximab

Figure 2

The reduction in PNH clone size over time. In March 2008, the CD59-deficient clone of WBCs and RBCs was detected when Budd-Chiari syndrome and intestinal ischemia were diagnosed. In April 2010, about 2 years after the first cycle of rituximab and 10 months after the second cycle of rituximab, there was significant decrease in size of the PNH clone in all cell lines.