About this Journal Submit a Manuscript Table of Contents
Case Reports in Hematology
Volume 2012 (2012), Article ID 197347, 3 pages
http://dx.doi.org/10.1155/2012/197347
Case Report

Primary Mediastinal Large B-Cell Lymphoma during Pregnancy

1Division of Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, Miami, FL 33136, USA
2Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, Miami, FL 33136, USA
3Department of Pathology, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, Miami, FL 33136, USA

Received 12 August 2012; Accepted 13 September 2012

Academic Editors: T. Sonoki, S. Storti, and P. Tsirigotis

Copyright © 2012 Cesar A. Perez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Non-Hodgkin’s Lymphoma (NHL) rarely presents during pregnancy and primary mediastinal large B-cell lymphoma (PMLBCL) accounts for approximately 2.5% of patients with NHL. The case of a 22-year-old woman who was diagnosed with Stage IIA PMLBCL during week 13 of her intrauterine pregnancy is described. The staging consisted in computed tomography (CT) of the chest and magnetic resonance imaging (MRI) of the abdomen and pelvis. She was managed with R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) for a total of six cycles and, because of the early presentation during the second trimester, she received the entire chemotherapy course during the pregnancy. She delivered a healthy baby at 34 weeks of pregnancy and a 18FDG-PET/CT scan demonstrated complete remission after delivery. After 20 months of follow up she remains with no evidence of disease and her 1-year-old son has shown no developmental delays or physical abnormalities. PMLBCL, although an uncommon subgroup of DLBCL, may present during pregnancy and R-CHOP should be considered as one suitable option in this complex scenario.