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Case Reports in Hematology
Volume 2012 (2012), Article ID 428279, 4 pages
http://dx.doi.org/10.1155/2012/428279
Case Report

Cytogenetics Findings in a Histiocytic Sarcoma Case

1Servicio de Hematología, Hospital Ramón y Cajal, Carretera de Colmenar Km 9, 100 28049 Madrid, Spain
2Servicio de Genética, Hospital Ramón y Cajal, Carretera Colmenar KM 9, 100 28034 Madrid, Spain

Received 29 December 2011; Accepted 19 February 2012

Academic Editors: R. Herrmann, K. Nakase, and S. D. Wagner

Copyright © 2012 J. M. Alonso-Dominguez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Histiocytic sarcoma (HS) is a neoplasm derived from histiocytes. Its diagnosis was not clear until its immunohistochemistry profile was correctly established. Not much is known about its genetic properties. We report a case of a 48-year-old male patient whose bone marrow was almost completely occupied by monomorphic medium size neoplastic cellularity. Its immunohistochemical profile was CD68+, CD4+, CD45+ with negativity of other dendritic cells, and other lineage markers. Cytogenetic study showed 4 related clones: one with trisomy 8 and extra material on the short arms of chromosome 4; a second line with tetrasomy of chromosome 8, add(4)(p16); the third clone had the same alterations as the previous and deletion of chromosome 3 at q11; the fourth line had tetrasomy 8 and translocation t(3;5)(q25;q35). To our knowledge this is the first HS case showing chromosome 8 trisomy and tetrasomy and the other described alterations.