Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin
Figure 2
Retrospective screening of the phyllodes tumor revealed focal epithelium-like areas within the stroma composed of pleomorphic cells (panel (a), lower part of the image) that strongly expressed CD61 (panel (b)) and which were sharply demarcated from the conventional spindle cell component of the tumor (upper part of panels (a) and (b)). Chromogenic in situ hybridization of centromere 17 (red nuclear signal, arrows) revealed monosomy 17 in both the epithelial (panel (c)) and the spindle cells (panel (d)) of the tumor. Also, fluorescent fusion probes flanking 13q14 showed only one copy per nucleus (panels (e) and (f)) in both tumor components.
