Hemophagocytic Lymphohistiocytosis in Association with Primary Cutaneous Anaplastic Large Cell Lymphoma

Figure 4

On immunohistochemistry the tumor cells showed uniform intense positivity for leukocyte common antigen (LCA) (a), CD3 (b), and CD30 (c), with a high proliferation index (Ki-67 = 70%) (d). Note the uniform, strong Golgi region positivity of CD30 (c) in the majority (>75%) of tumor cells. The cells were negative for pancytokeratin, CD20, anaplastic large cell lymphoma kinase (ALK), and epithelial membrane antigen (EMA) (Peroxidase-antiperoxidase stain, a and b; 100x, c; 200x).

(a)

(b)

(c)

(d)