Case Report
Idiopathic Acquired Hemophilia A with Undetectable Factor VIII Inhibitor
Table 1
Laboratory work-ups at the initial presentation and after 4 months of follow-up.
| | | Reference range | Initial presentation | 4-month follow-up |
| | aPTT (s) | 23.3–30.3 | 44.2 | NA | | aPTT ratio (PAT/normal) | — | 1.7 | NA | | Prothrombin time (s) | 9.4–11.6 | 10 | NA | | D-dimer (mg/L fibrinogen equivalent units) | 0.17–0.88 | 3.17 | NA | | Erythrocyte sedimentation rate (mm/hr) | 1–30 | 45 | NA | | FVIII activity (%) | 50–200 | 16 | 202 | | FVIII Inhibitor (Bethesda units/mL) | 0-1 | 0.0 | NA | | Von Willebrand factor antigen (% of normal) | 50–150 | >150 | NA | | 4 : 1 mix aPTT immediate (s) | 23.3–30.3 | 34.3 | NA | | 4 : 1 mix aPTT 2 hours (s) | 26.1–36.0 | 39.7 | NA | | Euglobulin lysis (min) | >60 | >60 | NA | | Ristocetin cofactor (%) | 50–150 | >149 | NA | | Serum IgG (mg/dL) | 751–1560 | 629 | NA | | Serum IgA (mg/dL) | 82–453 | 147 | NA | | Serum IgM (mg/dL) | 46–304 | 161 | NA | | Antinuclear antibody screen | — | Negative | NA |
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