Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab
Figure 1
(a) The lymph node is effaced by an infiltrate of lymphocytes with range of cytologic features ranging from large lymphocytes with prominent nucleoli to smaller lymphocytes and plasma cells (hematoxylin and eosin, 400x amplification). (b) Paraffin immunohistochemistry using antibodies against CD20 highlights B-cells with focal loose clusters (CD20, 100x magnification). (c) Small CD3 positive T cells are present in the background (CD3, 100x magnification). (d) Chromogenic in situ hybridization using probes to detect Epstein-Barr virus encoded RNA shows numerous EBV positive cells within the infiltrate, with many more EBV positive cells than would be expected in a lymph node with latent EBV infection (EBV-ISH, 100x magnification).
