Pure White Cell Aplasia and Necrotizing Myositis

Figure 2

Agranulocytosis with normal erythropoiesis and megakaryopoiesis. (a) Time-course of ANC during the admission showing severe neutropenia despite initiation of prednisone. Recovery of ANC to levels >2000 occurred after initiation of G-CSF and IVIG. (b) Bone marrow core biopsy showing paratrabecular region devoid of myeloid precursors but filled with erythroid precursors and occasional megakaryocytes. 400x. Scale bar 100 μm. (c) Bone marrow aspirate devoid of myeloid cells. 1000x. Scale bar 50 μm.

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