Erdheim-Chester Disease with No Skeletal Bone Involvement and Massive Weight Loss

Figure 5

Histologically, the hematoxylin and eosin (H&E) stain shows infiltration by histiocytes (a), 100X. The infiltrate is composed of bland-looking histiocytes with foam-cell and giant-cell forms (b), 200X. The histiocytes stain positive for CD68 immunostain (c) and negative for S100 immunostain (d).

(a)

(b)

(c)

(d)