Extensive Bone Marrow Necrosis: Initial Presentation in Sickle Cell Anemia—A Case Report and Review of the Literature

Figure 1

(a) Bone marrow aspirate showing an amorphous necrotic material (Giemsa stain ×100). (b) Extensive BMN in the trephine biopsy (H&E ×4). (c) Dilated sinus full of sickle cells in a background of ill-defined eosinophilic material (H&E ×40). (d) Intact area with erythroid hyperplasia (H&E ×40). (e) Spectrin stain showing the extent of erythroid hyperplasia (IHC, spectrin ×10).

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