Breast Implant-Associated Anaplastic Large Cell Lymphoma: Case Report and Review of the Literature

Table 2

Summary of management of BIA-ALCL in patients presenting with mass and/or lymph node involvement and effusion alone.

Reference	Age, years	Effusion	Mass	Lymph node involvement	Treatments (given in order listed)
Mass/node involvement
Zimmerman et al. [21]	48	Yes	No	Yes	6 cycles CHOP, bilateral total capsulectomy, 2 cycles salvage chemotherapy, 3 cycles anti-CD30 therapy with brentuximab vedotin, scheduled to receive stem cell transplant
Hwang et al. [22]	48	Yes	Yes	No	Unilateral capsulectomy, CHOP
Parthasarathy et al. [23]	43	No	Yes	Yes	2 cycles CHOP, cisplatin + gemcitabine, unilateral mastectomy with axillary nodes, RT (40 Gy in 15 fractions)
Tardio and Granados [24]	50	No	No	Yes	Bilateral capsulectomy, 4 cycles CHOP, RT
Effusion only
Bautista-Quach et al. [25]	52	Yes	No	No	6 cycles CHOP
George et al. [26]	67	Yes	No	No	Bilateral capsulectomy
De Silva et al. [27]	38	Yes	No	No	Bilateral capsulectomy, RT (36 Gy in 20 fractions)
Smith and Ramsaroop [28]	33	Yes	No	No	6 cycles CHOP, bilateral capsulectomy
Wong et al. [29]	40	Yes	No	No	Bilateral capsulectomy, referred for CHOP and RT
Sorensen et al. [30]	59	Yes	No	No	Unilateral capsulectomy on affected side and bilateral removal of implants

CHOP, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone/prednisolone; RT, radiation therapy; Gy, Gray.