Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma

Figure 1

A PET/CT scan showed hypermetabolic lymphadenopathy involving cervical, supraclavicular, axillary, pelvic, and inguinal nodes and findings consistent with malignant infiltration of the bilateral kidneys and spleen (a). Low-power examination of the lymph node showed distortion of the lymph node architecture, with expansion of the paracortex (b) (H&E, 40X magnification). High-power examination of the paracortex showed a mixed inflammatory infiltrate with increased eosinophils and scattered large cells (c) (600X). An immunohistochemical stain for CD30 highlighted a patchy increase in large immunoblasts (d) (400X).

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