Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia

Table 2

Random chromosomal abnormalities after autologous hematopoietic recovery.

Days after the transplant (month)	Karyotype (number of cells)	Number of abnormal karyotypes	Number of the metaphase
At diagnosis	46,XX[20]	(0)	(20)
45 (1)	46,XX,t(8;11)(p23;p21)[1] / 46,XX,t(8;22)(p21;p13)[1] / 46,XX[18]	2	20
172 (24)	46,XX,t(2;3)(p23;q29)[1] / 46,XX[19]	1	20
886 (29)	46,XX,add(1)(p11),add(2)(p11.2),−8,add(12)(q13),+mar1[3] / 46,XX [17]	3	20
1257 (41)	46,XX,t(3;3)(p11;p25)[2] / 46,X,t(X;8)(p22.3;q13)[1] / 46,XX,t(11;15)(q23;q15)[1] / 46,XX[15]	4	19
1623 (53)	46,XX,del(7)(q?)[3] / 46,XX,t(12;15)(q24.1;q22)[1] / 46,XX,add(4)(q12),add(6)(p21),der(6)t(4;6)(q12;q21)[1] / 46,XX[15]	5	20
1819 (59)	46,XX,add(7)(q22)[1]/46,XX,t(1;3)(p36.3;p21)[1] / 46,X,?t(X;16)(q22;q24),t(1;13)(p35.3;q14)[1] / 46,XX,t(13;20)(q14;q13.1)[1] / 46,X,?inv(X)(p11.2q21),t(5;16)(q31;p13.3)[1] / 46,XX[15]	5	20
1861 (61)	46,XX,add(7)(q22)[2]/ 46,XX,del(7)(q22),add(19)(q13.3)[1]/ 46,XX[17]	3	20
2022 (66)	46,XX,t(5;11)(q13;q21)[1] / 46,XX,t(5;13)(q13;q21)[1] / 46,XX,t(5;9)(q22;q34)[1] / 46XX,t(1;15;13;13)(q32;q15;p12;q12),?t(4;11)(p16;q23)[1] / 46, XX[16]	4	20
2169 (71)	46,XX,t(3;3)(p25; q21)[1]/46,XX,t(7;11)(p13;q22)[1] / 46,XX,t(9;16)(q22;q24)[1] / 46,XX,t(16;21)(q12-13;q22)[1] / 46,XX[16]	4	20
2358 (77)	46,XX,t(4;5)(q35;q11.2)[2] / 46,XX,t(3;6)(q24;p25)[1] / 46,XX, add(10)(p13),−15,+mar[1] / 46,XX[16]	4	20
2547 (83)	46,XX,t(2;16)(q13;q24)[1] / 46,XX, t(2;4)(q37;q31)[1] / 46,XX,add(1)(p13),?add(3)(p25),der(22)t(1;22)(p22;q11.2)[1] / 46,XX[17]	3	20
2792 (91)	46,XX,der(1)inv(1)(p13;q21)t(1;5)(p13;q11.2),der(5)t(1;5)(p13;q11.2)[1] / 46,XX[19]	3	20
3184 (104)	46,XX,−4,add(5)(p15),−10,der(11)(q23),−12,−13,+4mar[1] / 46,XX,t(16;22)(q24;q11.2)[1] / 46,XX[18]	2	20
3821 (125)	45,XX,−2,t(3;9)(p25;q22)[1] / 46,XX,inv(11)(p15;q13)[1]/46, XX t(1;5)(p32;q13)[1] / 46,XX,−4,−5,−8,−10,−22,+5mar[1] / 47,XX,+5[1] / 46,XX[15]	5	20
4211 (138)	44,XX,t(1;6)(q12;q21),−4,−13[1] / 46,XX,inv(10)(q11.2q24)[1] / 46,XX[18]	2	20
	Total number of analyzed cells after the transplant	50	299

Potential clone. The results of chromosomal analysis of bone marrow cells at several time points after allo-HSCT are shown above.