Clopidogrel-Induced Severe Hepatitis: A Case Report and Literature Review

Table 1

Clopidogrel-induced hepatitis: reported cases.

Cases	Latency/onset	Peak ALT (U/L)	Peak bilirubin (mg/dL)	Peak alkaline phosphatase (U/L)	Symptoms	Histology	Outcome
Keshmiri et al. 2016 (current)	135 days (4.5 months)	1567	37	130	Jaundice, fatigue	Hepatocellular	Recovery
Kapila et al. 2015 [9]	5 days	716	1.6	160	Nausea, vomiting, fever	No liver biopsy	Recovery
Pisapia et al. 2015 [2]	3 days	1603	24.5	408	Jaundice, arthralgia, papular rash	Mixed hepatocellular and cholestatic	Recovery
Monteiro et al. 2011 [13]	30 days	540	3.5	139	Nausea, vomiting	No liver biopsy	Recovery
Leighton et al. 2011 [11]	1 day	3626	3.3	364	Anorexia, jaundice, epigastric pain	Lymphoplasmacytic portal, interface and lobular hepatitis with no fibrosis	Recovery
Kastalli et al. 2010 [10]	19 days	336	4.7	186	Jaundice, abdominal pain	No liver biopsy	Death
Goyal et al. 2009 [3]	23 days	1011	7.3	1011	Abdominal pain, anorexia, jaundice	No liver biopsy	Recovery
Wiper et al. 2008 [4]	60 days	450	Normal	680	General malaise	No liver biopsy	Recovery
Lpez-Vicente et al. 2007 [12]	30 days	204	1.0	682	Abdominal pain, fever	No liver biopsy	Recovery
Ng et al. 2006 [5]	3 days	536	1.5	247	Fever, chills	No liver biopsy	Recovery
Hllmller et al. 2006 [1]	43 days	1003	20.8	221	Weight loss, anorexia, jaundice, nausea, abdominal pain	Mixed hepatocellular and cholestatic	Recovery
Chau et al. 2005 [7]	37 days	253	6.9	172	Jaundice	No liver biopsy	Recovery
Beltran-Robles et al. 2004 [6]	4 days	318	0.51	100	No symptoms mentioned	No liver biopsy	Recovery
Wolf et al. 2003 [16]	12 days	173	1.3	132	Fever, leukopenia, weakness	No liver biopsy	Recovery
Ramos Ramos et al. 2003 [14]	60 days	710	24.9	118	Jaundice	No liver biopsy	Recovery
Duran-Quintana et al. 2002 [8]	180 days	786	13	474	Icterus, hepatomegaly	No liver biopsy	Recovery
Willens 2000 [15]	21 days	507	3.0	636	Malaise, anorexia, myalgia, icterus	No liver biopsy	Recovery