Herpes Simplex Virus Hepatitis: A Presentation of Multi-Institutional Cases to Promote Early Diagnosis and Management of the Disease

Table 2

Epidemiology based on two large literature reviews.

	Norvell et al.	Kaufman et al.
	Number (%)	Number (%)
	137	52
Age (mean, yrs)	34	N/A
Gender		N/A
(i) Male	51/137 (38)
(ii) Female	86/137 (62)
Immunosuppressed	72/137 (53)	35/52 (67)
Pregnant	32/137 (23)	9/52 (17)
Fever	98/100 (98)	42/52 (82)
Herpetic lesions	54/123 (44)	29/52 (57)
Mean peak ALT or AST	4927	N/A
Leukopenia	50/70 (71)	22/52 (43)
Thrombocytopenia	59/63 (93)	23/52 (45)
Coagulopathy	93/111 (83)	10/52 (20)
Acute Renal Failure	34/52 (65)	N/A
Death
(i) Acyclovir	25/49 (51)	5/9 (55)
(ii) No Acyclovir	74/84 (88)	34/43 (80)

ALT: alanine aminotransferase; AST: aspartate aminotransferase; N/A: not available.