Retrospective Identification of Herpes Simplex 2 Virus-Associated Acute Liver Failure in an Immunocompetent Patient Detected Using Whole Transcriptome Shotgun Sequencing

Table 1

Laboratory data at time of admission.

Hematologic test
White blood cells (/μL)	3740
Neutrophils (%)	80
Lymphocytes (%)	6
Monocytes (%)	4
Eosinophils (%)	0
Basophils (%)	0
Red blood cells (×10^4/μL)	3.12
Hemoglobin (g/dL)	9.3
Platelet count (×10^4/μL)	1.1
Coagulation
Prothrombin time (%)	17
Prothrombin time-INR	2.92
Chemistry
Aspartate aminotransferase (IU/L)	8676
Alanine aminotransferase (IU/L)	5114
Total bilirubin (mg/dL)	4.3
Direct bilirubin (mg/dL)	2.7
Alkaline phosphatase (IU/L)	480
Lactate dehydrogenase (IU/L)	9120
γ-Glutamyltranspeptidase (IU/L)	206
Blood urea nitrogen (mg/dL)	6
Creatinine (mg/dL)	0.5
C-reactive protein (mg/dL)	3.06
Procalcitonin (ng/mL)	0.15
Total protein (g/dL)	5.3
Albumin (g/dL)	2.7
Sodium (mmol/L)	136
Chloride (mmol/L)	92
Potassium (mmol/L)	3.4
Ferritin (ng/mL)	34780
Copper (μg/dL)	53
Ceruloplasmin (mg/dL)	19
Ammonia (μmol/L)	17
IgG (mg/dL)	1028
IgM (mg/dL)	210
IgA (mg/dL)	206
Anti-nuclear antibodies (<)	×80
Hepatitis B surface antigen (IU/mL)	0.02
Hepatitis B core antibodies (COI)	0.1
Hepatitis C virus antibodies (COI)	0.1
IgM-hepatitis A virus antibodies	<0.4
Epstein-Barr virus
Anti-VCA IgG	80
Anti-VCA IgM	<10
Anti-VCA IgA	<10
Anti-EBNA antibodies	40
Cytomegalovirus
IgG (−)	26
IgM (−)	(−)
HIV-1,2 antibodies	(−)

COI: cut-off index; INR: international normalized ratio.