Resolution of Crizotinib-Associated Fulminant Hepatitis following Cessation of Treatment

Figure 2

(a) H&E-stained histologic section of the liver biopsy demonstrating severe acute hepatitis characterized by a panlobular mixed inflammatory infiltrate with extensive hepatocyte necrosis (200x magnification). (b) H&E-stained histologic section of the liver biopsy demonstrating bridging parenchymal necrosis (red arrow) and cholestasis (black arrow) (200x magnification). (c) Periodic acid-Schiff stained histologic section of the liver biopsy with diastase pretreatment highlighting numerous ceroid pigment-laden macrophages (red arrow) (200x magnification). (d) Reticulin-stained histologic section of the liver biopsy demonstrating areas of parenchymal collapse (red arrow) and regenerative thickening of the hepatocyte plates (black arrow) (100x magnification).

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