Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature

Table 1

Summary of patients with crizotinib-induced hepatotoxicity, characteristics, presentation, pattern of liver injury, and clinical outcome.

Year	Author	Number of cases	Age	Sex	Dosage	Duration of crizotinib exposure	Presenting symptoms	Pattern of liver injury	Mortality	Treatment	RUCAM score
2013	Ripault et al. [11]	1	69	F	500 mg qday	60 days	Fatigue	Hepatocellular	0	Withdrawal of medication with resolution	9
2014	Sato et al. [9]	1	54	F	400 mg qday	29 days	Epigastric pain	Hepatocellular	1	Withdrawal of the medication, steroids, plasma exchange	8
2016	Sassier et al. [12]	2	30, 62	M, F	250 mg/day	10 days, 30 days	None	Hepatocellular	0	Withdrawal of medication with resolution	7, 8
2016	Adhikari et al. [8]	1	56	M	250 mg BID	39 days	Fatigue, nausea/vomiting	Hepatocellular	1	NAC, mannitol, withdrawal of the medication, lactulose/rifaximin/LOLA/abx	9
2016	Van Geel et al. [7]	1	62	F	250 mg BID	24 days	Confusion	Hepatocellular	1	Supportive, withdrawal of the medication	8
2017	Brown et al. [13]	1	56	F	250 mg BID	6 weeks	Fatigue, weakness, darkening urine	Hepatocellular	1	NAC, withdrawal of the medication	NA
2017	Yasuda et al. [14]	1	51	F	250 mg BID	16 days	Abdominal pain, nausea, diarrhea	Hepatocellular	1	Steroids, supportive, withdrawal of the medication	6
2018	Charville et al. [15]	1	26	F	500 mg qday	10 weeks	Abdominal pain, jaundice	Hepatocellular	0	Withdrawal of medication with resolution, N-acetylcysteine	8
2018	Kesler et al. [16]	1	69	F	250 mg BID	4 weeks	Weakness, lightheadedness and hypotension	Hepatocellular	1	Withdrawal of the medication, lactulose/rifaximin/antibiotics	NA
2019	Zhang et al. [17]	1	37	M	250 mg BID	55 days	Dyspnea, abdominal pain	Hepatocellular	1	Withdrawal of the medication, lactulose/rifaximin/antibiotics	8
2019	Ota et al. [18]	1	66	F	250 mg BID	23 days	Fever, fatigue	Mixed	0	Withdrawal of the medication with resolution	7
2019	Kreitman et al. (Present case)	1	46	F	200 mg BID	8 weeks	Fatigue, abdominal pain, jaundice	Hepatocellular	0	Withdrawal of the medication, NAC	8

M, male; F, female; NA, not applicable (cannot be calculated).