Persistent Lymphadenopathy due to IgG4-Related Disease

Table 1

Differential diagnosis with pertinent laboratory findings^*.

Lymphoma	Bone marrow and lymph node biopsy performed HTLV-1+2 antibodies (nonreactive)
Castleman's disease	HHV-8 lymph node stains negative
Autoimmune Lymphoproliferative syndrome	Less than 1.5% double negative (CD4−CD8−) T-cell count on cytometry
Mycobacterial infection	AFB culture of lymph node (negative)
Systemic lupus erythematosus	ANA panel (1 : 160)
	Anti-dsDNA and anti-Sm antibodies (negative)
	Complement levels C3, C4 within normal range
Viral infections	EBV (nuclear Ag IgG positive, viral capsid IgG positive, viral capsid IgM negative),
	CMV (IgM negative, IgG negative), parvovirus B19 (IgM negative, IgG negative),
	Hepatitis (HBs Ag negative, HBc Ab negative, HBs Ab negative, HCV Ab negative)
Cat scratch disease	Bartonella panel (negative)
Sjögren's syndrome	SSA/SSB (negative)

*HTLV-1+2: human T-lymphotropic virus type I and II, HHV-8: human herpes virus 8; AFB: acid-fast bacilli, ANA: antinuclear antibodies, Anti-dsDNA: antidouble-stranded DNA, Anti-Sm: anti-Smith; EBV = Epstein-Barr virus, CMV: cytomegalovirus, HBs Ag = hepatitis B surface antigen, and HBc Ab: hepatitis B core antibody IgG, HBs Ab = hepatitis B surface antibody, HCV Ab: hepatitis C virus antibody, SSA: anti-Ro/SSA antibodies, and SSB: anti-La/SSB antibodies.