A Case of Anti-SAE1 Dermatomyositis

Figure 2

Skin biopsy and ANA determination. (a) H&E staining showing vacuolar changes in the basal layer of the epidermis (arrow) and perivascular lymphocytic infiltration of the dermis. (b) The IIF HEp-2 pattern showing a positive ANA with combined nuclear dense (AC-2) and fine speckled (AC-4) pattern (http://www.ANApatterns.org), the latter being compatible with anti-SAE1 reactivity. Arrows indicate fine speckled nucleoplasm in mitotic cells outside chromatin mass.

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