Case Report

Development of Peptic Ulcer following Second Shot of Sputnik V Vaccine: A Case Report and Literature Review of Rare Side Effects of Sputnik V Vaccine

Table 1

Summary of case reports on Sputnik V vaccines rare side effects.

First authors (references)Side effectSex/ageSymptomsPhysical examination and laboratory findingsDosage of the vaccineThe time between the onset of symptoms and the injection of the vaccineLaboratory test performed to exclude other etiologiesTreatment

Naghashzadeh et al. [23]Lymphocytic myocarditisMan/29Chest pain and generalized malaiseFever tachycardia (110 b.p.m)
Hypotension (95/60 mmHg), S3 was noted
ST-segment elevation in V3–V4
Troponin 3.04 ng/mL (normal range <0.02), WBC 13 500/mm3
2nd2 daySerum PCR testings for coxsackievirus, SARS-CoV-2, hepatitis C virus, and human immunodeficiency virus
The PCR test on endocardial biopsy for examination SARS-CoV-2, cytomegalovirus, adenovirus, human herpes virus-6 (HHV6), parvovirus B19, enterovirus, and influenza
Methylprednisolone, prednisolone, and mycophenolate mofetil and medical treatment for heart failure: enalapril, carvedilol, and spironolactone

Etemadifar et al. [24]Acute relapse MSFemale/34Severe right hemiplegia and ataxiaMuscle force was 2/5 and 3/5 in her right lower and upper limbs knee and biceps reflexes were 2+, bilaterally. No sensory deficits1st3 dayNRIntravenous methylprednisolone (500 mg/day) was administered for five consecutive days

Baimukhamedov et al. [25]Seropositive rheumatoid arthritisFemale/38Pain and morning stiffness appeared in the left and right shoulder and small joints of her hands and feet, swelling and pain in both knee jointsElevated levels of rheumatoid (RA) factor (170 IU/mL), erythrocyte sedimentation (39 mm/h), C-reactive protein (10 mg/L) and anticitrullinated protein antibodies (ACPA) (157 U/mL). DAS28-CRP (6.02). The immunoenzyme SARS-CoV-2 spike IgG antibody test was strongly positive1st20 DayThe antinuclear antibody (ANA) screen test, chlamydia and ureaplasma immunoenzyme test, uric acid level (241 mmol/L), serological anti‐SARS‐CoV‐2 rapid testMethotrexate (15 mg per week), NSAID, and methylprednisolone (100 mg infusion daily for 3 days)

Baimukhamedov et al. [26]Left elbow joint arthritisMan/58Joint swelling, pain, and stiffness upon movementSARS‐CoV‐2 spike IgG was 2.68 with a positivity coefficient of 13.42nd5 daySARS‐CoV‐2 PCR, immunoglobulin G (IgG) and IgM antibodies to SARS‐CoV‐2, chlamydia, urea plasma immunoenzyme
RA factor, anticyclic citrullinated peptides, and antistreptolysin O levels
NSAID, physiotherapy, and a single intra‐articular injection of diprospan (0.5 mL)

Our casePUDFemale/28Nausea, vomiting, and epigastric painIn endoscopy: severe ulceration and severe edema in the lower part of the esophagus, large circumferential ulcer in the body, and antrum
In pathology: severe inflammation, PMN dominant infiltration, less lymphocyte and eosinophil in lamina propria associated with red cell extravasation and multiple foci of hemorrhage
2nd5 daySARS‐CoV‐2 PCR, triple staining of gastric mucosal biopsies for H. pylori, gastrin levelPantoprazole 40 mg Q6 hrs