Case Report

A Putative Case of Methotrexate-Related Lymphoma: Clinical Course and PET/CT Findings

Figure 2

Pathology: (a) H and E section of liver core biopsy with dense infiltrate of small lymphocytes, original magnification 100X. (b) CD3 immunostain showing predominance of small T cells, original magnification 400X. (c) CD20 immunostain showing rare positive small B cells (arrows), original magnification 400X. (d) EBV encoded RNA in-situ hybridization (EBER), original magnification 400X. (e) H and E section of right axillary lymph node showing cluster of abnormal follicles, original magnification 100X. (f) CD21 immunostain showing intact but focally effaced follicular dendritic meshworks, original magnification 100X. (g) BCL6 immunostain showing many positive cells in follicles, original magnification 100X. (h) BCL2 immunostain with numerous negative cells in follicles, original magnification 100X. (i) H and E section of juxta-gastric lymph node demonstrating diffuse infiltrate of histiocytes and small and large lymphoid cells, original magnification 100X. (j) CD20 immunostain highlighting large lymphoid cells within infiltrate, original magnification 400X. (k) BCL6 immunostain showing scattered positive cells, including large lymphoid cells, original magnification 400X. (l) EBV encoded RNA in-situ hybridization (EBER), original magnification 100X.
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