Familial Adenomatous Polyposis—Rendering a Diagnosis Based on Recognition of an Unusual Primary Thyroid Neoplasm
Figure 1
Histological features of CMV variant of PTC. Representative pictures of the tumour show the cribriform structures composed of follicles deficient in colloid and lined by flattened to low cuboidal epithelial cells with scant intervening fibrous tissue (a). The tumor cells were weakly positive by immunohistochemistry for thyroglobulin ((a)-inset), but showed nuclear localization with immunostaining for beta-catenin ((b)-inset). Other portions of the tumor nodules had a trabecular arrangement (b, c) of tall columnar cells with small whorls of cells (arrowheads). The cells within the whorls had nuclei with a pale eosinophilic to clear appearance (c). A minor papillary component was present within the periphery of the tumor nodule (d). The tumor cell nuclei were oval and overlapping with irregular outlines. Nuclear grooves were readily identified and occasional typical intranuclear cytoplasmic pseudoinclusions were present. Magnification bar: (a) ×40, (b & d) ×100, and (c) ×200.
