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Case Reports in Medicine
Volume 2012 (2012), Article ID 140780, 3 pages
http://dx.doi.org/10.1155/2012/140780
Case Report

Guillain-Barré Syndrome Associated with Primary Parvovirus B19 Infection in an HIV-1-Infected Patient

1Service of Internal Medicine, Department of Internal Medicine, Mid-Valais Hospital Center, 81, Avenue Grand-Champsec, 1950 Sion, Switzerland
2Service of Infectious Diseases, Central Institute of the Valais Hospitals, 86, Avenue Grand-Champsec, 1950 Sion, Switzerland
3Service of Neurology, Department of Internal Medicine, Mid-Valais Hospital Center, 81, Avenue Grand-Champsec, 1950 Sion, Switzerland

Received 30 April 2012; Accepted 14 October 2012

Academic Editor: Aaron S. Dumont

Copyright © 2012 Caroline Bucher Praz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Parvovirus B19 (B19V) infection has rarely been reported as responsible for Guillain-Barré syndrome (GBS). We present the case of a 63-year-old man with AIDS who presented with rapidly progressing weakness of his inferior limbs and a newly appeared pancytopenia. CSF examination and electromyography were characteristic for GBS. Very high CSF and serum B19V DNA concentrations were present, in the absence of IgG or IgM against B19V. The neurologic and hematologic abnormalities improved after a 5-day course of i.v. immunoglobulins in parallel with a dramatic decrease in the B19V viral load.