Case Report
An Atypical Presentation of Brucellosis in a Patient with Isolated Thrombocytopenia Complicated with Upper Gastrointestinal Tract Bleeding
Table 1
Differential diagnosis of thrombocytopenia.
| | (1) Pseudothrombocytopenia |
| | (2) Congenital thrombocytopenia |
| | (3) Acquired thrombocytopenia | | (a) Platelet sequestration | | (i) Hypersplenism | | (b) Decreased production | | (i) Neoplasia (bone marrow infiltration or cytotoxic drugs) | | (ii) Viruses (EBV, CMV, rubella, varicella, parvovirus) | | (iii) Megaloblastic anemia | | (c) Increased destruction | | (i) Immune-mediated (ITP, neonatal alloimmune thrombocytopenia, drug-induced ITP, post transfusion, autoimmune diseases, | | lymphoproliferative disorders, HIV, HCV, Helicobacter pylori infections, HIT) | | (ii) Not immune-mediated (vascular prostheses, DIC, TTP/HUS, HELLP, eclampsia) |
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Abbreviations: EBV: Epstein-Barr virus; CMV: cytomegalovirus; ITP: idiopathic thrombocytopenic purpura; HIV: human immunodeficiency virus; HCV: hepatitis C virus; HIT: heparin-induced thrombocytopenia; DIC: disseminated intravascular coagulation; TTP: thrombotic thrombocytopenic purpura; HUS: heamolytic uraemic syndrome; HELLP: heamolysis, elevated liver enzymes, low platelets. Adapted from Veneri et al. [13].
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