A Case of Persistent Foot Pain in a Neurofibromatosis Type I Patient

Figure 1

Urgent MRI of the right lower limb; T1 weighted (left), T2 weighted (right). A large (approx. 15 cm), oval, smoothly defined heterogenous mass with a large necrotic centre is clearly visible behind the lower femur (white arrows). There is also an area of altered signal within the femur itself involving the condyle, suggestive of bony metastasis (white arrowheads). The likely diagnosis is malignant peripheral nerve sheath tumor (MPNST) with a differential diagnosis of lymphoma or other soft tissue sarcoma. The character and distribution of the pain could signify a sciatic nerve origin.